Performance of CT colonography for detecting small, diminutive, and flat polyps.

The primary goal of colorectal cancer screening and prevention is the detection and removal of advanced neoplasia. Computerized tomography (CT) colonography is now well established as an effective screening test. Areas of greater uncertainty include the performance characteristics of CT colonography for detecting small (6-9 mm), diminutive (< or =5 mm), and flat (nonpolypoid) lesions. However, the actual clinical relevance of small, diminutive, and flat polyps has also been the source of debate. This article addresses these controversial and often misunderstood issues.